When Satoshi and his mother accompany Professor Ookido to the distant Isshu region, Satoshi discovers Pokémon that he’s never seen before… and that he can’t wait to catch! He may have Pikachu at his side together with new friends Iris and Dent, but he’ll still need plenty of new Pokémon on his team if he wants to challenge Isshu's expert Gym Leaders. His quest to become a Pokémon Master just got even tougher!